Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Meanwhile the services PMI reading for the month was 51.2. It had been 52 in October. The manufacturing PMI, reported earlier this week, came in at 48.6 in November, versus expectations of 48.3. It had been 48.3 in October
The Kings also still owe a future first (unprotected in 2019 at worst) to Philly for the honor of being able to sign Rajon Rondo, Kosta Koufos, and Marco Belinelli. Talk about a team with no damn plan.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.
Trends and targets in antiviral phototherapy
Any 'jobs recovery is years away in most cities, ' says USA Today. And in reviewing famed analyst Meredith Whitney's new book, 'The Fate of States, ' she warns that 'excessive pensions crowd out both liberal goals such as education spending and tax cuts that conservatives want.'
Targeted poverty alleviation
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.在这欢乐的时节给你我最真的祝福和亲切的思念，愿你今年的新年比往年更璀璨。
Diagnostic technologies for COVID-19: a review
不会。结束罗伯特穆加贝(Robert Mugabe)长达37年的执政（军方在这件事上也帮了点忙）后，埃默森姆南加古瓦(Emmerson Mnangagwa)承诺在2018年举行自由选举。这引出了一个问题：他可能会输掉大选。他至少要装作选举是公平的，因为他需要政治献金来扭转经济。这将意味着要推行选举改革——可能会让其不受欢迎的非洲民族联盟-爱国阵线(Zanu-PF)输掉选举。即使姆南加古瓦准备好在选举中赌一把，还不清楚军方愿不愿意。已经把自己的人推上台的津巴布韦将军们，不太可能会容许公众再把他踢下去。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Facebook CEO Mark Zuckerberg
5.Britons love bleak humour: that's why all the hire bikes are branded with the name of a bank currently being investigated for fixing interest rates. It's supposed to be funny.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
1. "Game of Thrones" (5.9 million)
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
China has become the world's largest industrial robot market since 2013, and currently its domestic suppliers are moving up the supplier chain by offering more high-end products in recent years, added the report.
Antiviral drug discovery: broad-spectrum drugs from nature
And regarding Ukraine, the Russian president again denied that there are Russian troops operating inside eastern Ukraine where a pro-Russian separatist movement is fighting Ukrainian government troops. But he said Moscow never denied that "certain people" were there carrying out tasks "in the military sphere." He said Russia plans no sanctions against Ukraine, but will not extend preferential trade to Kyiv.
潘通色彩研究所(Pantone Color Institute)的执行总监莱亚特丽斯·艾斯曼(Leatrice Eiseman)说：把这两种颜色组合起来反应出“一种令人慰籍的秩序感与和平感”，在这个全球动荡和缺乏安全感的时代，把这种感觉融入产品应该具有吸引力。它也暗示着，“我们”和“他们”之间没有界线。
The show started with a circus theme, complete with acrobats, a sword-swallower and a man on stilts. Justin Bieber, Rihanna and Bruno Mars performed.
Influenza neuraminidase: A druggable target for natural products
On January the U.S. government levied a $70 million fine on Honda for failing to disclose, as required, more than 1,700 deaths and injuries in its vehicles to the National Highway Traffic Administration (NHTSA).
Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).
“Even though I’m an engineer and an analytical person at heart, the most important decisions I’ve ever made had nothing to do with any of that,” he told an interviewer at Duke University, where he studied for an MBA, last year. “They were always based on intuition.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
'It's a crazy resemblance,' Carlson said. 'Every time I watch [the movie], it's weird because it's like I'm watching myself. It's kind of creepy.'
The host list of 2014 Spring Festival Gala, including Zhu Jun, Dong Qing, Bi Fujian, Li Sisi and Zhang Guoli, are released on Wednesday. Chinese film actor and director Zhang Guoli will host the annual gala of China Central Television (CCTV) for the first time.
The role of biosensors in the detection of emerging infectious diseases
The top 10 Weibo celebrities now have a combined 40 million followers. One of the most famous online figures, Papi Jiang, already signed a contract for video ads worth a staggering $3.4 million.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Zhu Xueqin, an NPC deputy and migrant worker from Shanghai.
Consumers in many parts of the world have a preference for buying local which has helped boost the value of local brands.
Chinese tourism to South Korea has boomed in recent years, delighting retailers but irking domestic tourists who have found the country’s attractions swamped with visitors.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Anxiety has been fanned by the build-up of corporate debt in emerging markets, which doubled between 2008 and 2014 and has been one of the fastest growing areas of the global bond market.
"There are ways to control air (pollution), but we need stronger determination to control it." ZHANG LIJUN, member of the CPPCC National Committee and former vice-minister of environmental protection
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
A study cited in an article from Harvard University suggests your diet could have a significant impact on your memory as you age. Scientists at Brigham and Women's Hospital published a study within the "Annals of Neurology" that suggested women who ate high levels of saturated fat in foods like red meat and butter didn't perform as well on memory tests than women who regularly consumed less saturated fat. Researchers haven't yet discovered the connection between saturated fat and memory, but they hypothesize it could have something to do with a person's genes. Scientists and doctors have long recommended that patients work to control their cholesterol levels as they age to protect the memory during the aging process.
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
The job market faces challenges. Some five million Americans have been out of work for six months, raising the risk their skills will erode and make it even harder for them to find jobs down the road. And fears of slowing revenue growth could keep a lid on hiring by companies. About 36% of U.S. executives expect the head count at their firm to fall, according to an October survey by advisory firm CEB, compared with 29% who said that during the summer.[qh]
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Trium’s alumni value studying alongside senior and international classmates. “It allowed us to exchange [ideas] among ourselves and derive as much additional knowledge as [we gained] from the course itself,” says one.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Comic skit “You’ve Got Trouble”(Sun Tao, Qin Hailu etc)
I did not create the characters inAldnoah. I made the mainframe of the story until the preliminary version. Butin fact Inaho's character is different than what I wrote. I don't really have aconnection with this character, so this is an exception.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The clothes had resonance because the characters who wore them were intricate and multidimensional, not just because Joan’s brocade sheath was really glamorous, or Megan’s psychedelic chiffons made Pucci feel cool.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
"The Hunger Games" star ranks first on the 2012 edition of AskMen.com's "Top 99 Most Desirable Women" list. The poll, which collected more than 2.4 million votes, asked the website's readers to choose their favorite female celebrities based on their looks, personality, talent and other desirable characteristics.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
As PC use declines, infecting them with viruses just won't be as much fun any more. I'd expect to see malware, worms and viruses jump onto tablets and phones. As a consequence, we will all have to start protecting our devices more assiduously.
瑞茜·威瑟斯彭（Reese Witherspoon）刚出道时大胆尝试不同戏路的演出，据报道，她曾努力将因影片《一往直前》（Walk the Line）获得的最佳女主角的奖杯制成门环或项链。但这两种方案都没能得以实现，现在，小金人就站在她的客厅里。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The Australian pop star Sia noticed Maddie on the programme and last year she tweeted her to ask if she would appear in one of her videos... the rest is history.
The questions New Yorkers ask the column are dictated not only by their individual circumstances but also by the larger issues of the day, like rising housing costs, gentrification and shoddy construction. In the end, 2014 was a year of things going up — home prices, rents and, above all, buildings, with 16,700 units approved for construction through October, according to the Real Estate Board of New York.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The drama and the original game have a large fan base and enjoy great popularity in China, and even elsewhere in Asia.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Personal per capita disposable income increased by 6.3 percent in real terms.
Regulators in other countries will draw lessons from the success or failure of the Japanese model.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields)，去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称：“遗产是蕴藏着前景的历史。”他超爱这句话，说了不止一次。这句话被他翻来覆去地说，让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
The dip for the Caixin gauge, which concentrates on smaller and private manufacturers, stands in contrast to a pickup for China’s official manufacturing PMI, which focuses primarily on large, state-owned enterprises. The divergence may indicate that smaller outfits have been hit harder by pollution curbs and other regulatory tightening than their larger, state-run competitors, which also enjoy privileged access to state-run lenders.
9. Occupational therapist
201001/93725.shtmlNews trumpedcelebrities in 2010 as the BP oil spill in the Gulf of Mexico and World Cup soccer in South Africa topped the list of most-searched items of 2010, according to Yahoo!
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
In this post, we’ll take a look at 16 software applications that I use almost every day — and discuss why you should too.
Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
After 'Gravity' and 'American Hustle,' my picks are in alphabetical order:
The value of goods that crossed international borders last year fell 13.8 per cent in dollar terms — the first contraction since 2009 — according to the Netherlands Bureau of Economic Policy Analysis’s World Trade Monitor. Much of the slump was due to a slowdown in China and other emerging economies.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Remedy: While the idea of being your own boss is an attractive one, not everyone is cut out to be an entrepreneur. Being responsible for your own success, creating a legacy for your family and improving the lives of clients and customers certainly sounds romantic, but what about the long hours, the lack of leisure time, the risk of financial failure, the fact that you’re the boss, entry-level employee, marketer, accountant and janitor all rolled into one? If you value job stability, prefer a singular focus over multi-tasking, aren’t particularly comfortable with risk and can’t imagine yourself hustling for new business on a daily basis, the entrepreneurial lifestyle isn’t for you.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Ah yes, the other reason Sacramento shouldn't tank: Philadelphia has the option to swap picks with them this year. It's actually impossible for the Kings to get the No. 1 pick because of that, and it hurts their chances at a top-three pick overall.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Mr Trump is almost a textbook demagogue.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
报告指出，中国网游开发商自今年年初以来一直在考虑按照时间收费。在排名前十的网络游戏中，时间收费型网游占据了4个席位，其中两款是今年才开始商业化运营的新游戏，包括盛大互动娱乐有限公司(Shanda Interactive Entertainment)的主要新游戏《永恒之塔》(AION)。Cnzz.com说，转向时间收费模式更有可能给游戏带来公平和公正感，因为玩的最好的玩家将是那些花时间最多的人，而不是那些花钱最多的用户。
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
They are also less likely to seek employment in a different sector after graduation. Only 30 per cent changed industry sector compared with nearly two-thirds of full-time MBA students.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In the meantime, the sheer total of bitcoin-related startups that launched in 2014 demonstrates bitcoin’s momentum. There is no definitive listing of every single bitcoin startup, but 2014 almost certainly saw the launch of more of them than in any year prior. Data that AngelList sent to Fortune confirms that. In 2011, five bitcoin startups listed themselves on AngelList. In 2012 that number grew to 13. In 2013 it jumped to 193, and last year it exploded to 566. (But not all startups register on AngelList immediately, if at all.) In addition, on January 8 the total number of daily bitcoin transactions hit an all-time high, as Barry Silbert eagerly tweeted.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
差不多人人都知道谷歌的分析工具Google Analytics，但是你是否用过谷歌的网站管理员工具(Google Webmaster Tools)？作为一名营销人员，我认为谷歌的网站管理工具是我用过的最重要的免费工具之一。你肯定想让自己公司的名字出现在谷歌搜索结果之中，对吧？那么为什么不听听谷歌网站管理员工具教给你的诀窍呢？
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
With an increase of 7 percent over 2013,total spending on medicines will amount to $1.06trillion in 2014, says the report"The Global Use of Medicines: Outlook through2018" from the IMS Institute for Healthcare Informatics, releasedThursday.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
But because I can’t help but hope that with the end of “Mad Men” comes the end of a period in fashion that has seen designers become trapped in the past to an almost stifling degree. At least the past as it looked in the 1960s (which in the beginning, let us not forget, looked a lot like the late 1950s) and early ’70s.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
China purchased 141,000 industrial robots in 2017, up 58.1% year-on-year, but foreign brands accounted for nearly three quarters of that, showing that the gap is still widening between Chinese robot makers and their foreign peers.
Need to send gigantic files (up to 2gb) quickly? Try WeTransfer.com. You don’t even have to create an account. I use it almost every day.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Or, this year, to be women with a story to tell about abuse, sexual or otherwise — a couple of whom shared #MeToo moments in our pages. Carlotta Gall told the story of Henda Ayari, a French citizen of North African heritage and anti-Salafist activist who accused a prominent Oxford professor of raping her.
Anti-HIV drug repurposing against SARS-CoV-2
6. 现在，就像瘾君子戒不了毒一样，格罗斯在其博客“Tipping Point”中写道，QE将维持到2015年。“暂时没有名字的泡沫”早前似乎应该改名叫“贝南克泡沫”。但现在事关格罗斯及其太平洋投资管理公司(Pimco)的二万亿美元，或许我们应该称之为“格罗斯泡沫”。
But at the end of a madcap Golden Globes (Ms. Fey toasted it as 'the beautiful mess we hoped it would be'), the major honors soberly ended up with the favorites. David O. Russell's con-artist caper 'American Hustle' led with three awards, including best film comedy. And despite missing out in the other six categories it was nominated in, the unflinching historical drama '12 Years a Slave' concluded the night as best film drama.
Length-scale dependence of protein hydration-shell density
Three Billboards Outside Ebbing, Missouri
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The University of Pittsburgh team used stem cells made from skin to make MCPs, a special kind of cell that acts as a precursor to cardiovascular tissue. They then placed these cells on a 3-D scaffold designed to support a mouse heart. Within 20 days, the new heart began beating at 40 to 50 beats per minute.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
All but one of the other top 10 categories reflected public fascination with celebrities. Teen pop sensation Miley Cyrus was in third place in the search rankings and television personality Kim Kardashianwas not far behind at fourth place. They were followed by Lady Gaga at No. 5, actress Megan Fox in seventh place, with Justin Bieber, American Idol and Britney Spears completing the top 10. The iPhone stood out as the exception, coming in sixth.
About this collection
I hope you have a most happy and prosperous New Year.