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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

受到好的affect影响就充满爱affection,受到不好的影响affect就学会假装affected
在面试期间看手机,嚼口香糖。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Meanwhile the services PMI reading for the month was 51.2. It had been 52 in October. The manufacturing PMI, reported earlier this week, came in at 48.6 in November, versus expectations of 48.3. It had been 48.3 in October
The Kings also still owe a future first (unprotected in 2019 at worst) to Philly for the honor of being able to sign Rajon Rondo, Kosta Koufos, and Marco Belinelli. Talk about a team with no damn plan.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

看看这些:

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

巴蒂表示,中国的大学现如今已经花费百万元巨资聘请国际知名学者,同时还配备了各项最先进的设备。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

五大发展理念:创新、协调、绿色、开放、共享的发展理念
Helsinki-based developer Remedy Entertainment has blurred the line between Hollywood and games with previous incarnations Max Payne and Alan Wake. Now the studio is combining next-generation visuals with the tension and drama of scripted television. Set in the university town of Riverport, Quantum Break puts players in control of Jack Joyce and Beth Wilder, a pair of ordinary people who are given the extraordinary power to manipulate time after an accident that creates a time rift. Time will randomly break down during the game, which causes disasters in the environment that pause, stutter, rewind and freeze. Fans of Max Payne’s bullet time will see new strategies emerge with gunfights involving time-amplified combat as the player fights against the Monarch Corporation. In addition to the virtual storyline, the game features custom live action storytelling that’s personalized based on the decisions one makes.
Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.
Summly和雅虎拒绝对交易的条款置评。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Any 'jobs recovery is years away in most cities, ' says USA Today. And in reviewing famed analyst Meredith Whitney's new book, 'The Fate of States, ' she warns that 'excessive pensions crowd out both liberal goals such as education spending and tax cuts that conservatives want.'
8.Wheel Skates
品牌价值增长最快的行业是服装,由运动服饰耐克(Nike)和快时尚品牌Zara引领,因为人们更多地关注健康和健身,同时Zara的快时尚在中国变得越来越受欢迎。
Targeted poverty alleviation

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

identical

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

日本央行会收紧货币政策吗?

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 家具回收价太低 市民换新不容易
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

年龄:45岁
单词debut 联想记忆:

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: “见义勇为好市民”落户积20分
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.在这欢乐的时节给你我最真的祝福和亲切的思念,愿你今年的新年比往年更璀璨。
卓越雇主排名:1

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

不会。结束罗伯特穆加贝(Robert Mugabe)长达37年的执政(军方在这件事上也帮了点忙)后,埃默森姆南加古瓦(Emmerson Mnangagwa)承诺在2018年举行自由选举。这引出了一个问题:他可能会输掉大选。他至少要装作选举是公平的,因为他需要政治献金来扭转经济。这将意味着要推行选举改革——可能会让其不受欢迎的非洲民族联盟-爱国阵线(Zanu-PF)输掉选举。即使姆南加古瓦准备好在选举中赌一把,还不清楚军方愿不愿意。已经把自己的人推上台的津巴布韦将军们,不太可能会容许公众再把他踢下去。
以我所有的爱心与真诚祝你及全家圣诞快乐。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

美国银行集团
Facebook CEO Mark Zuckerberg
斜着头,怒目,像受到惊吓的狗狗那样
5.Britons love bleak humour: that's why all the hire bikes are branded with the name of a bank currently being investigated for fixing interest rates. It's supposed to be funny.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

中国富豪王健林旗下拥有AMC Theaters等产业,在今年的榜单上进入了前20位。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

1. "Game of Thrones" (5.9 million)
但大部分海外岛屿则会出售永久产权。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

汉森表示,美国原油增产意味着现货油价对地缘政治事件的反应不如以往那样大了。他说,目前的原油供应足够多,油价受威胁的程度不如以往,2014年将是首个出现一段时间原油供应增量超过需求增量的年头。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

China has become the world's largest industrial robot market since 2013, and currently its domestic suppliers are moving up the supplier chain by offering more high-end products in recent years, added the report.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

And regarding Ukraine, the Russian president again denied that there are Russian troops operating inside eastern Ukraine where a pro-Russian separatist movement is fighting Ukrainian government troops. But he said Moscow never denied that "certain people" were there carrying out tasks "in the military sphere." He said Russia plans no sanctions against Ukraine, but will not extend preferential trade to Kyiv.
潘通色彩研究所(Pantone Color Institute)的执行总监莱亚特丽斯·艾斯曼(Leatrice Eiseman)说:把这两种颜色组合起来反应出“一种令人慰籍的秩序感与和平感”,在这个全球动荡和缺乏安全感的时代,把这种感觉融入产品应该具有吸引力。它也暗示着,“我们”和“他们”之间没有界线。
The show started with a circus theme, complete with acrobats, a sword-swallower and a man on stilts. Justin Bieber, Rihanna and Bruno Mars performed.
艾瑞咨询集团和中国最火的微博平台——新浪微博在上海的一个论坛上发布了该报道。该论坛由微博和通信巨头华为联合举办。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 全国建材家居4月销售上涨三成
Review Article

Influenza neuraminidase: A druggable target for natural products

On January the U.S. government levied a $70 million fine on Honda for failing to disclose, as required, more than 1,700 deaths and injuries in its vehicles to the National Highway Traffic Administration (NHTSA).
其他国家的监管机构将以日本模式的成功或失败为借鉴。
Unlicensed drivers who engage in the services will face a fine ranging from 10 thousand yuan ($1,500) to 30 thousand yuan ($4,500).
谷歌2017搜索排名靠前的包括马特·劳尔和飓风厄玛。搜索巨头公布了它今年的年度搜索结果榜单,内容主要是在全球各类行业中谷歌搜索排名靠前的几位。
“Even though I’m an engineer and an analytical person at heart, the most important decisions I’ve ever made had nothing to do with any of that,” he told an interviewer at Duke University, where he studied for an MBA, last year. “They were always based on intuition.”

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

'It's a crazy resemblance,' Carlson said. 'Every time I watch [the movie], it's weird because it's like I'm watching myself. It's kind of creepy.'
The host list of 2014 Spring Festival Gala, including Zhu Jun, Dong Qing, Bi Fujian, Li Sisi and Zhang Guoli, are released on Wednesday. Chinese film actor and director Zhang Guoli will host the annual gala of China Central Television (CCTV) for the first time.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 挥汗战高温 建好还迁房
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The top 10 Weibo celebrities now have a combined 40 million followers. One of the most famous online figures, Papi Jiang, already signed a contract for video ads worth a staggering $3.4 million.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

查看全部解释

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Zhu Xueqin, an NPC deputy and migrant worker from Shanghai.
Consumers in many parts of the world have a preference for buying local which has helped boost the value of local brands.
Q=Dd[(U=ze~+vR_uAR%
Chinese tourism to South Korea has boomed in recent years, delighting retailers but irking domestic tourists who have found the country’s attractions swamped with visitors.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

法学、工学、医学的毕业生签约月薪较高,平均值分别是5545元、4512元、4500元,同去年相比略有下降,而教育学、农学的毕业生签约月薪偏低,分别为3258元和3184元。
Cnzz.com的报告还讨论了目前在中国网络游戏行业盛行的装备收费模式问题。举例来说,很多美国游戏公司都是按照时间收费的,但大多数中国网络游戏都采取了装备收费模式,玩家可以免费试玩。用户玩游戏的时间越长,就越有可能花钱购买游戏装备,以获得更高的游戏级别。但这也意味着花钱最多的玩家就在游戏中表现最好。
Anxiety has been fanned by the build-up of corporate debt in emerging markets, which doubled between 2008 and 2014 and has been one of the fastest growing areas of the global bond market.
"There are ways to control air (pollution), but we need stronger determination to control it." ZHANG LIJUN, member of the CPPCC National Committee and former vice-minister of environmental protection

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

protocol
“有个员工烤了个蛋糕,把辞职信直接写在了蛋糕上。”

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

也许经济增长率是否能达到3%的国内最大威胁是利率的突然调整,但是从各方面的预测来看鸽派的美联储在2015年不太可能会采用挑衅的利率策略。
这种成功的感觉本身也可以带来一种身份认同。
A study cited in an article from Harvard University suggests your diet could have a significant impact on your memory as you age. Scientists at Brigham and Women's Hospital published a study within the "Annals of Neurology" that suggested women who ate high levels of saturated fat in foods like red meat and butter didn't perform as well on memory tests than women who regularly consumed less saturated fat. Researchers haven't yet discovered the connection between saturated fat and memory, but they hypothesize it could have something to do with a person's genes. Scientists and doctors have long recommended that patients work to control their cholesterol levels as they age to protect the memory during the aging process.
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
民主党最有可能的竞争对手、共和党参选人特朗普则对Fox新闻表示,希拉里这是在讨好女性选民。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

时间:2009-10-22 编辑:vicki
The job market faces challenges. Some five million Americans have been out of work for six months, raising the risk their skills will erode and make it even harder for them to find jobs down the road. And fears of slowing revenue growth could keep a lid on hiring by companies. About 36% of U.S. executives expect the head count at their firm to fall, according to an October survey by advisory firm CEB, compared with 29% who said that during the summer.[qh]
receptive

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

n. 无限
adj. 有营养的,滋养的

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

(可可英语版权所有,未经允许请勿转载)
Trium’s alumni value studying alongside senior and international classmates. “It allowed us to exchange [ideas] among ourselves and derive as much additional knowledge as [we gained] from the course itself,” says one.
小女孩名叫Neshama Spielman,来自耶路撒冷。她是4年前在“圣殿山筛选项目”中发现这个护符的。该项目旨在检查从神圣犹太教遗址移来,未经考古检测过的泥土。当年,Spielman只有8岁。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Comic skit “You’ve Got Trouble”(Sun Tao, Qin Hailu etc)
I did not create the characters inAldnoah. I made the mainframe of the story until the preliminary version. Butin fact Inaho's character is different than what I wrote. I don't really have aconnection with this character, so this is an exception.
江苏、山东、浙江、河南和四川的经济总量排名紧随其后,名次与2015年相同。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 北京新建商品房价格同比微降
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

The clothes had resonance because the characters who wore them were intricate and multidimensional, not just because Joan’s brocade sheath was really glamorous, or Megan’s psychedelic chiffons made Pucci feel cool.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

"The Hunger Games" star ranks first on the 2012 edition of AskMen.com's "Top 99 Most Desirable Women" list. The poll, which collected more than 2.4 million votes, asked the website's readers to choose their favorite female celebrities based on their looks, personality, talent and other desirable characteristics.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 上市房企“白银时代”谋转型
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

As PC use declines, infecting them with viruses just won't be as much fun any more. I'd expect to see malware, worms and viruses jump onto tablets and phones. As a consequence, we will all have to start protecting our devices more assiduously.
瑞茜·威瑟斯彭(Reese Witherspoon)刚出道时大胆尝试不同戏路的演出,据报道,她曾努力将因影片《一往直前》(Walk the Line)获得的最佳女主角的奖杯制成门环或项链。但这两种方案都没能得以实现,现在,小金人就站在她的客厅里。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

n. 火焰,热情
The Australian pop star Sia noticed Maddie on the programme and last year she tweeted her to ask if she would appear in one of her videos... the rest is history.
10、 因为与邦德在一起很有趣,女人往往会迷上他,这在人际关系中很重要,也是很多首次约会一拍即合的秘诀。甚至派去杀他的女特工也会爱上他。研究证明,这也不奇怪,007的形象常被批成大男子主义,也许不错--但是,只能让他在女人面前的魅力有增无减。
The questions New Yorkers ask the column are dictated not only by their individual circumstances but also by the larger issues of the day, like rising housing costs, gentrification and shoddy construction. In the end, 2014 was a year of things going up — home prices, rents and, above all, buildings, with 16,700 units approved for construction through October, according to the Real Estate Board of New York.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

选择出国继续学习的学生比例也出现小幅下降,由去年的4.8%下降至3.4%。
The drama and the original game have a large fan base and enjoy great popularity in China, and even elsewhere in Asia.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Personal per capita disposable income increased by 6.3 percent in real terms.
Regulators in other countries will draw lessons from the success or failure of the Japanese model.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields),去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称:“遗产是蕴藏着前景的历史。”他超爱这句话,说了不止一次。这句话被他翻来覆去地说,让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 碧桂园推出家居装修“私人定制”
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

The dip for the Caixin gauge, which concentrates on smaller and private manufacturers, stands in contrast to a pickup for China’s official manufacturing PMI, which focuses primarily on large, state-owned enterprises. The divergence may indicate that smaller outfits have been hit harder by pollution curbs and other regulatory tightening than their larger, state-run competitors, which also enjoy privileged access to state-run lenders.
“阅后即焚”社交网络的兴起
9. Occupational therapist
201001/93725.shtmlNews trumpedcelebrities in 2010 as the BP oil spill in the Gulf of Mexico and World Cup soccer in South Africa topped the list of most-searched items of 2010, according to Yahoo!

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

仅过去6个月,这家诞生于澳大利亚的公司不断从亚马逊(Amazon)、贝宝(PayPal)、谷歌(Google)和Twitter挖角,其高管团队的实力由此大大增强。同时,它还与行业领导者Magento公司签署了一项备受关注的协议,后者承诺将为该公司引入数以千计的新客户。它最近撤销了旧金山新办公室的租约,由于人员扩张非常快,如今公司需要的办公空间已是当初预期的3倍。
亲朋好友称Ross是一个充满活力有梦想的女孩子,她走到哪里,都会被她点亮。她去世后几天,她的母亲Alicia Jesquith告诉记者,女儿突然离世,她需要一个答案。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

这些模子能让普通水果长出有趣的形状。
In this post, we’ll take a look at 16 software applications that I use almost every day — and discuss why you should too.
Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 高起点、高质量创新微晶石产品
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

After 'Gravity' and 'American Hustle,' my picks are in alphabetical order:
The value of goods that crossed international borders last year fell 13.8 per cent in dollar terms — the first contraction since 2009 — according to the Netherlands Bureau of Economic Policy Analysis’s World Trade Monitor. Much of the slump was due to a slowdown in China and other emerging economies.
北京、上海等城市都存在严重的空气污染问题。北京1月份爆发了近期最为严重的雾霾,而去年12月上海空气污染指数一度爆表。严重的空气污染问题显然无助于吸引更多外国游客前来旅游。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 稳投资 有储备有信心
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

特朗普与中国的贸易战
Remedy: While the idea of being your own boss is an attractive one, not everyone is cut out to be an entrepreneur. Being responsible for your own success, creating a legacy for your family and improving the lives of clients and customers certainly sounds romantic, but what about the long hours, the lack of leisure time, the risk of financial failure, the fact that you’re the boss, entry-level employee, marketer, accountant and janitor all rolled into one? If you value job stability, prefer a singular focus over multi-tasking, aren’t particularly comfortable with risk and can’t imagine yourself hustling for new business on a daily basis, the entrepreneurial lifestyle isn’t for you.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Ah yes, the other reason Sacramento shouldn't tank: Philadelphia has the option to swap picks with them this year. It's actually impossible for the Kings to get the No. 1 pick because of that, and it hurts their chances at a top-three pick overall.
从投资决策角度来看,2014年是有史以来最糟糕的年景之一,几乎可以说是全盘皆输。除了少数华尔街亿万富豪才玩得起的“股东积极主义”维权策略还算奏效外,没有哪种投资策略在这一年里始终灵光。
一些科学家说,2014年成为创下气温纪录的一年,最值得注意的一点是该年度并没有发生强大的厄尔尼诺现象,一种由于太平洋将巨大的热量输送到大气层所造成的大尺度天气模式。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
From the themed collection: 科学引导小农户合理利用土地
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

2018年,反对科技巨擘(Big Tech)的声音将扩散到科技行业雇员群体,很多人质疑他们所做的工作是否真的在拯救世界。
Mr Trump is almost a textbook demagogue.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

“我们从斯雷布雷尼察大屠杀事件了解了荷兰和荷兰人是什么样的,”埃尔多安说起现代荷兰历史上最可耻的一幕,“我们从他们屠杀那里的8000名波斯尼亚人就知道,他们品德败坏到何等地步。”
“If you were going to be betting, you would bet its going to be warmer than 2015,” said Mr Karl.
effective

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

X

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

报告指出,中国网游开发商自今年年初以来一直在考虑按照时间收费。在排名前十的网络游戏中,时间收费型网游占据了4个席位,其中两款是今年才开始商业化运营的新游戏,包括盛大互动娱乐有限公司(Shanda Interactive Entertainment)的主要新游戏《永恒之塔》(AION)。Cnzz.com说,转向时间收费模式更有可能给游戏带来公平和公正感,因为玩的最好的玩家将是那些花时间最多的人,而不是那些花钱最多的用户。
每一次我们詹姆斯已经达到了顶点,詹姆斯就会拿出更好的表现超过那个顶点。他那无所不包的各项技巧,是詹姆斯辛苦训练的证明。你可以嘲笑他所提发布的所有Instagram录像,但这些都是他仍然能够做到这一点的真正原因;詹姆斯从来不轻视他的每一场比赛,一次都没有。结果便是晚上一次又一次无可比拟的表演。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

['k?mf?t]
adj. 概要的,简略的

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 智能家居缺乏统一标准成发展瓶颈
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

9月份CPI录得1.6%的同比涨幅后,经济学家曾预测10月份的同比涨幅为1.5%。中国政府为今年全年设定的通胀目标为“3%左右”。
They are also less likely to seek employment in a different sector after graduation. Only 30 per cent changed industry sector compared with nearly two-thirds of full-time MBA students.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

In the meantime, the sheer total of bitcoin-related startups that launched in 2014 demonstrates bitcoin’s momentum. There is no definitive listing of every single bitcoin startup, but 2014 almost certainly saw the launch of more of them than in any year prior. Data that AngelList sent to Fortune confirms that. In 2011, five bitcoin startups listed themselves on AngelList. In 2012 that number grew to 13. In 2013 it jumped to 193, and last year it exploded to 566. (But not all startups register on AngelList immediately, if at all.) In addition, on January 8 the total number of daily bitcoin transactions hit an all-time high, as Barry Silbert eagerly tweeted.
《佛罗里达乐园》

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 家居市场将提前进入“放假”状态
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

所估计的收入来自电影、电视、化妆品及其他公司代言。宝莱坞女星迪皮卡?帕度柯妮是唯一一位首次入围的女星。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

差不多人人都知道谷歌的分析工具Google Analytics,但是你是否用过谷歌的网站管理员工具(Google Webmaster Tools)?作为一名营销人员,我认为谷歌的网站管理工具是我用过的最重要的免费工具之一。你肯定想让自己公司的名字出现在谷歌搜索结果之中,对吧?那么为什么不听听谷歌网站管理员工具教给你的诀窍呢?
尽管欧洲工商管理学院与清华大学的合办项目重新跌至亚军位置,但欧洲工商管理学院自己的EMBA项目的排名却上升3个位置,排在第四位,该项目上次获得第4名是在2011年。
怎样拥有平坦小腹
目前还不清楚绑架者的身份以及他们的目的。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

With an increase of 7 percent over 2013,total spending on medicines will amount to $1.06trillion in 2014, says the report"The Global Use of Medicines: Outlook through2018" from the IMS Institute for Healthcare Informatics, releasedThursday.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 卫浴洁具市场投诉的焦点问题
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

But because I can’t help but hope that with the end of “Mad Men” comes the end of a period in fashion that has seen designers become trapped in the past to an almost stifling degree. At least the past as it looked in the 1960s (which in the beginning, let us not forget, looked a lot like the late 1950s) and early ’70s.
Jordan、harley、robert、matthew、daniel、andrew、andrea、joshua等人名都出现在榜单上,football(足球)和lakers(湖人队)也上榜。
这枚奖牌在拍卖会上以95万美元的价格成交,但是需要额外支付的买方佣金使得最终的拍卖价格达到116万美元。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

10月份,尽管中国出台了大量限购措施,中国新建住宅价格增速却仍然加快。
除非查尔斯-奥克利成功控诉纽约老板詹姆斯-多兰,尼克斯2016-17赛季唯一的亮点将是克里斯塔普斯-波尔津吉斯在全明星周末斩获技巧挑战赛冠军。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

China purchased 141,000 industrial robots in 2017, up 58.1% year-on-year, but foreign brands accounted for nearly three quarters of that, showing that the gap is still widening between Chinese robot makers and their foreign peers.
Need to send gigantic files (up to 2gb) quickly? Try WeTransfer.com. You don’t even have to create an account. I use it almost every day.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 红星美凯龙抵制天猫双11活动
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Or, this year, to be women with a story to tell about abuse, sexual or otherwise — a couple of whom shared #MeToo moments in our pages. Carlotta Gall told the story of Henda Ayari, a French citizen of North African heritage and anti-Salafist activist who accused a prominent Oxford professor of raping her.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

6. 现在,就像瘾君子戒不了毒一样,格罗斯在其博客“Tipping Point”中写道,QE将维持到2015年。“暂时没有名字的泡沫”早前似乎应该改名叫“贝南克泡沫”。但现在事关格罗斯及其太平洋投资管理公司(Pimco)的二万亿美元,或许我们应该称之为“格罗斯泡沫”。
至少希拉里今年赢得了点什么。我相信她会非常兴奋。
But at the end of a madcap Golden Globes (Ms. Fey toasted it as 'the beautiful mess we hoped it would be'), the major honors soberly ended up with the favorites. David O. Russell's con-artist caper 'American Hustle' led with three awards, including best film comedy. And despite missing out in the other six categories it was nominated in, the unflinching historical drama '12 Years a Slave' concluded the night as best film drama.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

2010财年,这家超级零售商可抱怨的地方不多。利润增加,而且由于销售额增长,该公司再次攀升至《财富》500强的冠军。今年沃尔玛的单店销售额和去年几乎持平,但同塔吉特百货销售额下降2.5%相比,持平已算不错。最值得注意的是沃尔玛重塑形象。前任首席执行官李?斯科特扩大了对员工医疗保险的覆盖,更关注环境,经常在公共场合露面,这些都起到了积极作用。当然,总会有人批评,而且沃尔玛第一季度的表现也不是最好的。但无可否认,斯科特给新任首席执行官麦克?杜克留下的是一个斗志昂扬的公司。
课程安排:伊利诺州埃文斯顿校区授课时间为每隔一周的周五至周日;佛罗里达州迈阿密校区每月上一次课,授课时间为周四下午至周日中午
Three Billboards Outside Ebbing, Missouri
2014年最佳引擎榜单的其他入选者还包括宝马5系豪华轿车和紧凑型雪佛兰科鲁兹(Cruze)所使用的涡轮增压柴油发动机,保时捷Cayman双座运动跑车的水平对置2.7升6缸发动机以及大众汽车捷达紧凑车的1.8升4缸涡轮增压发动机。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

愿节日的愉快伴你一生。
The University of Pittsburgh team used stem cells made from skin to make MCPs, a special kind of cell that acts as a precursor to cardiovascular tissue. They then placed these cells on a 3-D scaffold designed to support a mouse heart. Within 20 days, the new heart began beating at 40 to 50 beats per minute.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

蒋依依说,2013年人民币兑美元汇率上涨近3%,使北京成为了一个更加昂贵的旅游目的地。
[d?'mestik]
All but one of the other top 10 categories reflected public fascination with celebrities. Teen pop sensation Miley Cyrus was in third place in the search rankings and television personality Kim Kardashianwas not far behind at fourth place. They were followed by Lady Gaga at No. 5, actress Megan Fox in seventh place, with Justin Bieber, American Idol and Britney Spears completing the top 10. The iPhone stood out as the exception, coming in sixth.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

I hope you have a most happy and prosperous New Year.
发行于2013年的《炫富帮》是一部语带讽刺的犯罪剧情片,记录了一帮好莱坞山高中生的冒险,他们偷到了当地名人的家里。少年们进入梅根·福克斯和帕丽斯·希尔顿这样的偶像家,偷走现金、衣服、手袋和珠宝,用来模仿杂志上让他们羡慕的奢华生活。在朋友圈炫耀战利品的照片后,他们终于被抓进了监狱。

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